Voltage-Gated Ion Channel Accessory Subunits: Sodium, Potassium, or Both?
نویسندگان
چکیده
منابع مشابه
Voltage-gated ion channel accessory subunits: sodium, potassium, or both?
Commentary The voltage-gated potassium channel subunit Kv4.2 is a pore-forming alpha subunit of A-type potassium channels. Kv4.2, encoded by the KCND2 gene, is broadly expressed in the central nervous system and is predominantly localized on neuronal dendrites, with increased density on distal dendrites (1). A-type potassium channels are important regulators of neuronal excitability, modulating...
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Our laboratory previously cloned a novel rabbit gene (Kcn1), expressed in kidney, heart, and aorta, and predicted to encode a protein with 58% amino acid identity with the K channel Shaker Kv1.3 (Yao X et al. Proc Natl Acad Sci USA 92: 11711-11715, 1995). Because Kcn1 did not express well (peak current in Xenopus laevis oocytes of 0.3 microA at +60 mV), the human homolog (KCNA10) was isolated, ...
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ژورنال
عنوان ژورنال: Epilepsy Currents
سال: 2013
ISSN: 1535-7597,1535-7511
DOI: 10.5698/1535-7511-13.1.30